While I'm no Jim Winstead I used the Amazon Honor System yesterday to give to the Red Cross. "1-click donation". Very easy. Go do it already. Vani found a PDF or some such at the redcross.org site detailing how they are spending the money - most importantly they don't spend an unreasonable amount on paper pushing.
When I gave 18,000 people had given a total of $900,000 via the Amazon system. Now it's at close to $3,000,000 from 50,000 people.
If you don't want to give to the Red Cross, you can maybe give a little money to Doctors Without Borders.